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TAMpering with toll-like receptor signaling
Authors:O'Neill Luke A J
Institution:School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland. laoneill@tcd.ie
Abstract:Toll-like receptors (TLRs) provoke a profound inflammatory response during host defense and must be controlled in order to avoid autoimmune and inflammatory diseases. In this issue, Rothlin et al. (2007) uncover a complex negative feedback mechanism to limit TLR signaling involving the Tyro3/Axl/Mer (TAM) family of receptor tyrosine kinases, which induce expression of the inhibitory proteins SOCS1 and SOCS3.
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