TAMpering with toll-like receptor signaling |
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Authors: | O'Neill Luke A J |
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Institution: | School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland. laoneill@tcd.ie |
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Abstract: | Toll-like receptors (TLRs) provoke a profound inflammatory response during host defense and must be controlled in order to avoid autoimmune and inflammatory diseases. In this issue, Rothlin et al. (2007) uncover a complex negative feedback mechanism to limit TLR signaling involving the Tyro3/Axl/Mer (TAM) family of receptor tyrosine kinases, which induce expression of the inhibitory proteins SOCS1 and SOCS3. |
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