Prostaglandins E1 and E2 stimulate release of intestinal brush border enzymes |
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| Authors: | R Mirhom R Eloy JP Vaultier A Ananna G Clendinnen JF Grenier |
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| Institution: | Unit of Surgical Research and Biophysiopathology of the Intestine INSERM 61, Avenue Molière 67200 Strasbourg France |
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| Abstract: | Rat small bowel was perfused
and
in the absence of biliary and pancreatic secretion. Intraluminal release of sucrase, alkaline phosphatase, aminopeptidase and enterokinase was significantly increased after administration of PG E1 and E2 1 and 5 μg/kg. This suggests a direct stimulation of the intestinal mucosa, which might be mediated through cyclic AMP ; dibutyryl cAMP significantly stimulates intraluminal release of proteins, sucrase and enterokinase. |
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