Genome-wide linkage scans for loci affecting total cholesterol, HDL-C, and triglycerides: the Family Blood Pressure Program |
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| Authors: | Suzette J Bielinski Weihong Tang James S Pankow Michael B Miller Thomas H Mosley Eric Boerwinkle Richard A Olshen J David Curb Cashell E Jaquish D C Rao Alan Weder Donna K Arnett |
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| Institution: | (1) University of Minnesota, Division of Epidemiology and Community Health, West Bank Office Building Suite 300, 1300 South 2nd Street, Minneapolis, MN 55454, USA;(2) Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, MS, USA;(3) Human Genetics Center, University of Texas–Houston Health Science Center, Houston, TX, USA;(4) Division of Biostatistics, Stanford University School of Medicine, Stanford, CA, USA;(5) Pacific Health Research Institute, Honolulu, HI, USA;(6) Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD, USA;(7) Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA;(8) University of Michigan Hospitals, Ann Arbor, MI, USA;(9) Department of Epidemiology, University of Alabama, Birmingham, AL, USA |
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| Abstract: | Atherosclerosis accounts for 75% of all deaths from cardiovascular disease and includes coronary heart disease (CHD), stroke, and other diseases of the arteries. More than half of all CHD is attributable to abnormalities in levels and metabolism of lipids. To locate genes that affect total cholesterol, high density lipoprotein cholesterol (HDL-C), and triglycerides, genome-wide linkage scans for quantitative trait loci were performed using variance components methods as implemented in SOLAR on a large diverse sample recruited as part of the Family Blood Pressure Program. Phenotype and genetic marker data were available for 9,299 subjects in 2,953 families for total cholesterol, 8,668 subjects in 2,736 families for HDL, and 7,760 subjects in 2,499 families for triglycerides. Mean lipid levels were adjusted for the effects of sex, age, age2, age-by-sex interaction, body mass index, smoking status, and field center. HDL-C and triglycerides were further adjusted for average total alcoholic drinks per week and estrogen use. Significant linkage was found for total cholesterol on chromosome 2 (LOD = 3.1 at 43 cM) in Hispanics and for HDL-C on chromosome 3 (LOD = 3.0 at 182 cM) and 12 (LOD = 3.5 at 124 cM) in Asians. In addition, there were 13 regions that showed suggestive linkage (LOD ≥ 2.0); 7 for total cholesterol, 4 for HDL, and 2 for triglycerides. The identification of these loci affecting lipid phenotypes and the apparent congruence with previous linkage results provides increased support that these regions contain genes influencing lipid levels.Electronic Supplementary Material Supplementary material is available to authorised users in the online version of this article at . |
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