Blood platelet serotonin following enterectomy in rats. |
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| Authors: | E E Osim J H Wyllie |
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| Affiliation: | Surgical Unit, Faculty of Clinical Sciences, University College London, Rayne Institute. |
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| Abstract: | The role of the intestine as a source of platelet serotonin was investigated. Radioactive serotonin precursor. 5-Hydroxytryptophan was injected into enterectomised and sham-operated rats. Blood samples were taken at time intervals and serotonin uptake was estimated by radioactive counting. Soon (1-2 hrs) after surgery and under sodium pentobarbital anaesthesia, platelet 5HT activity was higher in enterectomised rats than in controls. The intestine may not be the major source of platelet serotonin. |
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