Local serum levels of vascular endothelial growth factor in infantile hemangioma: Intriguing mechanism of endothelial growth |
| |
| Authors: | Przemysław Przewratil Anna Sitkiewicz Ewa Andrzejewska |
| |
| Affiliation: | 1. Department of Pediatric Surgery and Oncology, Medical University of Lodz;2. Department of Pathology, Medical University of Lodz;3. Department of Biochemistry, Medical University of Lodz;4. Department of Pediatric Surgery and Urology, Medical University of Gdańsk;1. Department of Pathology, Medical University of Lodz, ul. Pomorska 251, 92-216 Lodz, Poland;2. Department of Pediatric Surgery and Oncology, Central Clinical Hospital of Medical University of Lodz, Konopnicka Memorial Pediatric Center, ul. Sporna 36/50, 91-738 Lodz, Poland;3. Department of Developmental Pathology, Central Clinical Hospital of Medical University of Lodz, Konopnicka Memorial Pediatric Center, ul. Sporna 36/50, 91-738 Lodz, Poland;1. Department of School Psychology and Child and Adolescent Development, Tiensestraat 102 – Box 3717, 3000 Leuven, Belgium;2. Department of Parenting and Special Education, KU Leuven, Leopold Vanderkelenstraat 32 – Box 3765, 3000 Leuven, Belgium;1. Department of Dermatology, Kasr Al-Ainy Hospital, Cairo University, Cairo, Egypt;2. Department of Clinical and Chemical Pathology, Kasr Al-Ainy Hospital, Cairo University, Cairo, Egypt;3. Department of Pediatrics, Cairo University, Abo EL-Reesh Hospital, Cairo, Egypt |
| |
| Abstract: | The pathogenesis of hemangiomas still remains poorly understood. Dysregulation of angiogenesis has been proposed to play a central role in hemangioma pathogenesis. The aim of our study was to determine the peripheral and local serum levels of VEGF in patients with hemangiomas and vascular malformations. Material and methods: The study group consisted of 52 children with infantile hemangioma (33 with proliferative lesions, 19 with involuting lesions), 14 children with vascular malformations and 36 healthy children. VEGF serum levels were analyzed by an ELISA assay and the values between the groups were compared. Results: The serum peripheral VEGF concentrations in children with proliferative hemangiomas were significantly higher than in patients with involuting hemangiomas, vascular malformations and controls. There was no correlation between the measured cytokine level, hemangioma size, and the age of the patients. The local serum VEGF levels in 29 children with hemangiomas were distinctly lower than in the peripheral blood, both in 20 proliferating hemangiomas (p < 0.0001) and 9 involuting ones (p = 0.007); and the difference between females and males was non-significant (NS p = 0.06). Conclusions: (1) VEGF serum levels vary in the different phases of hemangioma growth and may help to distinguish hemangiomas from vascular malformations; (2) obtained local results may support the intrinsic theory of endothelial cell proliferation in hemangiomas. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
