Roles of endothelin-1 and selected proinflammatory cytokines in the pathogenesis of proliferative diabetic retinopathy: Analysis of vitreous samples |
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| Authors: | J. Adamiec-Mroczek J. Oficjalska-Młyńczak M. Misiuk-Hojło |
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| Affiliation: | 1. Department of Ophthalmology, King George’s Medical University, Lucknow, India;2. Developmental Toxicology Division, CSIR- Indian Institute of Toxicology Research, Lucknow, India;3. Department of Ophthalmology, Pallas Klinik, Olten, Switzerland;4. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic;5. 2nd Department of Internal Medicine, St. Anne´s University Hospital and Masaryk University, Brno, Czech Republic;1. Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, Japan;2. Department of Medicine, Kurume University School of Medicine, Kurume, Japan;1. School of Medicine, Iran University of Medical Sciences, Tehran, Iran;2. Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran;3. Stem Cell and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran;4. Health Promotion Research Center, Iran University of Medical Sciences, Tehran, Iran;5. Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, TX, USA;6. Department of Hematology and Blood Banking, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran;7. Department of Pharmacology, Zahedan University of Medical Sciences, Zahedan, Iran;8. Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran |
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| Abstract: | PurposeTo investigate the roles of endothelin-1(ET-1), TNF-α, IL-6 in the pathogenesis of proliferative diabetic retinopathy (PDR) in type 2 diabetes.MethodsVitreous and blood serum samples were collected during vitrectomy from 19 patients with PDR and 15 patients who underwent vitrectomy for other reasons. The concentrations of ET-1, TNF-α, IL-6, vWF, sE-selectin were determined by ELISA.ResultsIntraocular and serous concentrations of ET-1, TNF-α, IL-6, vWF, sE-selectin were higher in patients with PDR than in the control group. The vitreous ET-1/plasma ET-1 ratios the group of diabetic patients and in the control group were similar. Also TNF-α, IL-6 vitreous/plasma ratio were not statistically different between the analysed groups. Correlation between intraocular ET-1 and TNF-α concentrations in patients with PDR and between the increases in both factors in the vitreous and HbA1c concentration were shown. In the vitreous the increase in vWF depended on elevated levels of vWF in the serum. E-selectin concentration correlated with diastolic blood pressure.ConclusionThese data provide evidence of the activation of the local synthesis of ET-1, TNF-α, IL-6 in PDR. The relationship between the increase in vitreous ET-1, TNF-α concentrations and HbA1c concentration is a important confirmation of the necessity to optimise diabetes treatment. |
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