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Deletion of the adenosine A2A receptor increases the survival rate in a mice model of polymicrobial sepsis |
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| Authors: | Meriño Miguel Martín Sebastián San Sandaña Pedro Herlitz Kurt Aguayo Claudio Godoy Alejandro Torres-Vergara Pablo Gonzalez Marcelo Troncoso Felipe Acurio Jesenia Escudero Carlos |
| Institution: | 1.Vascular Physiology Laboratory, Group of Investigation in Tumor Angiogenesis (GIANT), Department of Basic Sciences, Faculty of Sciences, University of Bío-Bío, 3780000, Chillán, Chile ;3.Biomedical Research Centre, School of Medicine, Universidad de Valparaíso, Valparaíso, Chile ;4.Group of Research and Innovation in Vascular Health (GRIVAS Health), Chillán, Chile ;5.Anatomo-pathology Service, Clinical Hospital Herminda Martín, Chillán, Chile ;6.Universidad Católica de la Santísima Concepción, Concepción, Chile ;7.Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepción, Concepción, Chile ;8.Department of Urology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA ;9.Centro de Biología Celular y Biomedicina (CEBICEM), Universidad San Sebastián, Santiago, Chile ;10.Departamento de Farmacia, Facultad de Farmacia, Universidad de Concepción, Concepción, Chile ;11.Laboratorio de Investigación Materno-Fetal (LIMaf), Department of Obstetrics and Gynecology, Faculty of Medicine, University of Concepción, Concepción, Chile ; |
| Abstract: | Purinergic Signalling - We aim to investigate the role of A2A receptor in peritonitis-related sepsis by injection of a fecal solution (FS) as a model of polymicrobial infection. C57/black J6... |
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