Isoquinoline alkaloids from cell suspension cultures of Fumaria capreolata |
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Authors: | T. Tanahashi M. H. Zenk |
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Affiliation: | (1) Lehrstuhl für Pharmazeutische Biologie der Universität München, Karlstraße 29, D-8000 München 2, FRG;(2) Present address: Kobe Women's College of Pharmacy, Kobe, Japan |
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Abstract: | Fumaria capreolata was taken into cell suspension culture. The culture yielded a biomass of about 12 g dry weight per liter of medium; the dried cells contained ca. 0.1% of alkaloids. Besides choline, the following ten known isoquinoline alkaloids were isolated from the cell extract in crystalline form: coptisine, dehydrocheilanthifoline; (+)-isoboldine; magnoflorine; N-methylcoclaurine; (+)-reticuline; (–)-pallidine; protopine; sanguinarine; (–)-scoulerine. This is the most diverse isoquinoline alkaloid spectrum thus far published for a cell suspension culture. |
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