Effect of propionate and pyruvate on citrulline synthesis and ATP content in rat liver mitochondria. |
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| Authors: | L Cathelineau F P Petit F X Coudé P P Kamoun |
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| Institution: | Laboratoire de Biochimie Génétique, Groupe Hospitalier Necker-Enfants Malades 75730 Paris Cédex 15 France |
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| Abstract: | Propionate inhibits citrullinogenesis when succinate (plus rotenone) or glutamate are the oxidizable substrates used. Propionate decreases the intramitochondrial concentration of carbamylphosphate by decreasing the ATP content. When the energy supply for citrullinogenesis is provided by an influx of exogenous ATP, propionate is no longer an inhibitor. Pyruvate inhibits citrullinogenesis with glutamate but not with succinate (plus rotenone) as oxidizable substrates. Propionate and pyruvate deplete mitochondrial ATP but probably by different mechanisms. |
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