Cannabinoid induced degranulation of rabbit neutrophils |
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| Authors: | P H Naccache M Volpi E L Becker A Makryannis R I Sha'afi |
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| Institution: | 1. Department of Pathology and Physiology, University of Connecticut Health Center, Farmington, CT, USA.;2. Department of Medicinal Chemistry, University of Connecticut, Storrs, CT, USA.;3. Institute of Material Sciences, University of Connecticut, Storrs, CT, USA. |
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| Abstract: | We have examined the effects of various cannabinoids on the degranulation of rabbit peritoneal neutrophils. Several cannabinoids were found to cause a dose-dependent and noncytotoxic release of lysosomal enzymes from the neutrophils. The degranulation induced by cannabidiol is rapid (), and enhanced by extracellular calcium and cytochalasin B. In addition to their intrinsic activity, cannabinoids also modulate the neutrophils' responses to the chemotactic peptide formyl-methionyl-leucyl-phenylalanine. This investigation represents the initial step toward the characterization of the effect of cannabinoids on the excitation-activation coupling sequence of hormonally responsive cells. |
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