Application of Preserved Human Amniotic Membrane for Corneal Surface Reconstruction |
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| Authors: | Pinnita Prabhasawat Panida Kosrirukvongs Wipawee Booranapong Yongyudh Vajaradul |
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| Institution: | (1) Department of Ophthalmology; The Bangkok Biomaterial Center, Faculty of Medicine, Siriraj Hospital, Madhidol University, Bangkok, 10700, Thailand;(2) Department of Ophthalmology, Siriraj Hospital, Faculty of Medicine, Mahidol University, 2 Prannok Road, Bangkoknoi, Bangkok, 10700, Thailand;(3) Department of Ophthalmology, Thailand;(4) Department of Orthopedics, The Bangkok Biomaterial Center, Faculty of Medicine, Siriraj Hospital, Madhidol University, Bangkok, 10700, Thailand |
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| Abstract: | Objective: To evaluate the efficacy of preserved human amniotic membrane transplantation for reconstruction of the corneal surface diseases.
Methods: Preserved human amniotic membrane transplantations were performed in 84 eyes of 78 patients for corneal surface reconstruction. The indications were limbal stem cell deficiency from Steven–Johnson syndrome, chemical burn and herpes keratitis (27 eyes), bullous keratopathy (26 eyes), persistent epithelial defect and dellen (17 eyes), band keratopathy (11 eyes), preparing for prosthesis (1 eye), corneal ulcer (1 eye) and acute chemical burn (1 eye).
Results: Success was noted in 83.3% (70/84) eyes, partial success in 13.1% (11/84) eyes, and failure in 3.6% (3/84) eyes for an average follow-up of 10.5 months (3 – 29 months). No patient developed major immediate post-operative complications.
Conclusion: Amniotic membrane transplantation can reduce inflammation, promote corneal epithelial healing, and decrease irritation in corneal surface problems. |
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| Keywords: | amniotic membrane amniotic membrane transplantaion bullous keratopathy band keratopathy dellen descemetocele corneal surface reconstruction limbal stem cell deficiency persistent epithelial defect |
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