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Metabolism of Acetate to Amino Acids in Brains of Rats After Complete Hepatectomy
Authors:Gertrude M Tyce  Jauneita Ogg  Charles A Owen  Jr
Institution:Departments of Physiology and Biochemistry, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, U.S.A
Abstract:Abstract: The concentration of glutamine increases in the brain after hepatectomy. In the present studies the conversion of intravenously given 14C]acetate to 14C]glutamate and 14C]glutamine was studied in control rats and in rats at 6 h after complete hepatectomy. The incorporation of label into glutamate was only slightly inhibited, but the further incorporation into glutamine was greatly inhibited, after hepatectomy. These data, and previous data using 14C]glucose as precursor, indicate that synthesis of glutamine in brain is inhibited after hepatectomy, and suggest that its concentration must increase because degradation is inhibited to an even greater extent.
Keywords:Ammonia  Hepatic coma  Glutamate  Glutamine  Aspartate
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