Chromosomal changes in two strains of human fibroblasts cultured in vitro |
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| Authors: | H van Steenis |
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| Institution: | (1) Department of Radiation Genetics and Chemical Mutagenesis, University of Leiden, The Netherlands;(2) J. A. Cohen Institute for Radiopathology and Radiation Protection, University of Leiden, The Netherlands |
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| Abstract: | The chromosomal changes that occurred in two freshly initiated human cell strains, during their in vitro life were followed. Both strains are characterized by slow growth, and both show a period of delayed growth. In one of the strains the chromosomal composition showed changes just before the period of slow growth. After this period both cell strains showed several kinds of aneuploid chromosome complements, mainly in the hypotetraploid region. Aberrant chromosomes were present at the end of the in vitro life of both strains.The work in this paper was supported by the Foundation for Basic Medical Research (FUNGO), and the Association between Euratom and the University of Leiden, contract No. 052-64-1-BIAN. |
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