Biodegradation kinetics of poly(3-hydroxybutyrate)-based biopolymer systems |
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| Authors: | A P Boskhomdzhiev A P Bonartsev T K Makhina V L Myshkina E A Ivanov D V Bagrov E V Filatova A L Iordanskii G A Bonartseva |
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| Institution: | 1.A. N. Bach Institute of Biochemistry,Russian Academy of Sciences,Moscow,Russia;2.Faculty of Biology,M. V. Lomonosov Moscow State University,Moscow,Russia;3.N. N. Semenov Institute of Chemical Physics,Russian Academy of Sciences,Moscow,Russia |
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| Abstract: | The aim of this study was to evaluate and to compare the long-term kinetics curves of biodegradation of poly(3-hydroxybutyrate)
(PHB), its copolymer poly(3-hydroxybutyrate-co-3-hydroxyvalerate), and a PHB/polylactic acid composite. The total weight loss
and the change of average viscosity molecular weight were used as the parameters reflecting the biodegradation degree. The
rate of biodegradation was analyzed in vitro in the presence of lipase and in vivo after film implantation in animal tissues.
The morphology of the PHB film surface was studied by the atomic force microscopy technique. It was shown that PHB biodegradation
involves both polymer hydrolysis and its enzymatic biodegradation. The results obtained in this study can be used for the
development of various PHB-based medical devices. |
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