| UVA照射通过诱导HO-1的表达对细胞产生保护作用 |
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| 引用本文： | 施坤宁,王丽娟,李海滨,吕凤林,钟莉.UVA照射通过诱导HO-1的表达对细胞产生保护作用[J].生物物理学报,2010(11). |
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| 作者姓名： | 施坤宁 王丽娟 李海滨 吕凤林 钟莉 |
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| 作者单位： | 重庆大学生物工程学院111计划生物力学与组织修复工程基地教育部生物流变学与技术重点实验室; |
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| 基金项目： | 重庆自然科学基金(CSTC,2009BB5044); 重庆市科技攻关国际合作重大项目(2009AA5045)~~ |
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| 摘 要： | 长波紫外线A(UVA,320～400nm)照射皮肤后可产生活性氧族(reactive oxygen species,ROS),导致细胞损伤或免疫抑制,还能增强UVB的损伤作用。但也有研究表明,UVA照射不会产生免疫抑制,它可通过诱导血红素氧合酶1(HO-1)的表达减轻UVB照射引起的免疫抑制效应,从而对细胞产生保护作用。由于UVA照射引起的损伤或保护作用尚存在很大争议,本文主要结合近年来的相关研究,概括了适量UVA照射引起的免疫改变以及相关研究,总结了UVA照射诱导HO-1表达所发挥的细胞保护作用,尤其是HO-1的抗氧化和免疫保护作用,这将为深入了解UVA照射的反应机制和新型防晒剂的应用提供一定的指导意义。
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| 关 键 词： | UVA 皮肤免疫保护 血红素氧合酶1 |
UVA-mediated Heme Oxygenase1 Expression Contributes to UVA-induced Protection |
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| SHI Kunning,WANG Lijuan,LI Haibin,LV Fenglin,ZHONG Li The Base of Project for Biomechanics & Tissue Repair Engineering,Key Laboratory of Biorheological Science , Technology,Ministry of Education,Bioengineering College,Chongqing University,Chongqing ,China.UVA-mediated Heme Oxygenase1 Expression Contributes to UVA-induced Protection[J].Acta Biophysica Sinica,2010(11). |
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| Authors: | SHI Kunning WANG Lijuan LI Haibin LV Fenglin ZHONG Li The Base of Project for Biomechanics & Tissue Repair Engineering Key Laboratory of Biorheological Science Technology Ministry of Education Bioengineering College Chongqing University Chongqing China |
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| Institution: | SHI Kunning,WANG Lijuan,LI Haibin,LV Fenglin,ZHONG Li The Base of 111 Project for Biomechanics & Tissue Repair Engineering,Key Laboratory of Biorheological Science and Technology,Ministry of Education,Bioengineering College,Chongqing University,Chongqing 400044,China |
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| Abstract: | Long wave ultraviolet radiation(UVA,wave length range in 320~400 nm) generates reactive oxygen species that can lead to skin damage or immune-suppressive effects on some parts of immune system.It may also enhance the damage incurred due to the medium wave ultraviolet radiation(UVB,wave length range in 280~320 nm).Conversely,some studies indicate that UVA radiation will not induce the immunosuppression and can inhibit the UVB-induced immunosuppression via mediating the expression of heme oxygenase 1(HO-1) to... |
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| Keywords: | UVA Skin immunoprotection Heme oxygenase1 |
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