BglBricks: A flexible standard for biological part assembly |
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| Authors: | JChristopher Anderson John E Dueber Mariana Leguia Gabriel C Wu Jonathan A Goler Adam P Arkin and Jay D Keasling |
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| Institution: | (1) Department of Bioengineering, University of California, 94720 Berkeley, CA, USA;(2) QB3: California Institute for Quantitative Biological Research, University of California, 94720 Berkeley, CA, USA;(3) Physical Biosciences Division, Lawrence Berkeley National Laboratory, 94720 Berkeley, CA, USA;(4) Synthetic Biology Engineering Research Center, University of California, 94720 Berkeley, CA, USA;(5) Joint BioEnergy Institute, 947608 Emeryville, CA, USA;(6) Department of Chemical Engineering, University of California, 94720 Berkeley, CA, USA |
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| Abstract: | Background Standard biological parts, such as BioBricks™ parts, provide the foundation for a new engineering discipline that enables
the design and construction of synthetic biological systems with a variety of applications in bioenergy, new materials, therapeutics,
and environmental remediation. Although the original BioBricks™ assembly standard has found widespread use, it has several
shortcomings that limit its range of potential applications. In particular, the system is not suitable for the construction
of protein fusions due to an unfavorable scar sequence that encodes an in-frame stop codon. |
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