Evolutionary ancestry and novel functions of the mammalian glucose transporter (GLUT) family |
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| Authors: | Amy L Wilson-O'Brien Nicola Patron Suzanne Rogers |
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| Affiliation: | (1) Department of Medicine-St. Vincent's, The University of Melbourne, 3065 Fitzroy, Victoria, Australia;(2) Department of Genetics, The University of Melbourne, 3052 Parkville, Victoria, Australia;(3) Department of Botany, The University of Melbourne, 3052 Parkville, Victoria, Australia;(4) Department of Primary Industries, Victorian Agribiosciences Centre, 3983 Bundoora, Victoria, Australia;(5) Protein Chemistry and Metabolism Unit, St. Vincent's Institute of Medical Research, 3065 Fitzroy, Victoria, Australia |
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| Abstract: | Background In general, sugar porters function by proton-coupled symport or facilitative transport modes. Symporters, coupled to electrochemical energy, transport nutrients against a substrate gradient. Facilitative carriers transport sugars along a concentration gradient, thus transport is dependent upon extracellular nutrient levels. Across bacteria, fungi, unicellular non-vertebrates and plants, proton-coupled hexose symport is a crucial process supplying energy under conditions of nutrient flux. In mammals it has been assumed that evolution of whole body regulatory mechanisms would eliminate this need. To determine whether any isoforms bearing this function might be conserved in mammals, we investigated the relationship between the transporters of animals and the proton-coupled hexose symporters found in other species. |
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