DNA sequence comparison of micropia transposable elements fromDrosophila hydei andDrosophila melanogaster |
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Authors: | Dirk-Henner Lankenau Peter Huijser Erik Jansen Koos Miedema Wolfgang Hennig |
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Institution: | (1) Department of Molecular and Developmental Genetics, Catholic University, Toernooiveld, NL-6525 ED Nijmegen, The Netherlands;(2) Present address: Max-Planck-Institut für Züchtungsforschung, Egelspfad 3, D-5000 Köln 30, Federal Republic of Germany |
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Abstract: | Members of the retrotransposon family micropia were discovered as constituents of wild-typeY chromosomal fertility genes fromDrosophila hydei. Several members of the micropia family have subsequently been recovered fromDrosophila melanogaster and four micropia elements, micropia-DhMiF2, -DhMiF8, -Dm11 and-Dm2, two each fromD. hydei andD. melanogaster, have been totally sequenced (17 kb of micropia sequences and 6.8 kb from insertions)1. Comparative analysis of micropia sequences revealed a complex pattern of divergence within a singleDrosophila genome. The divergence includes deletions, possibly by a slipped mispairing mechanism, insertions of a retroposon, and of another retrotransposon (copia) and positional nucleotide shuffling within the tandem repeats of the 3 non-protein-coding region of micropia elements. A 10 bp long sequence of each repeat unit of the 3 tandem repeats of micropia elements is highly conserved and is therefore a candidate of functional importance either in transposition events or in regulatory activity on flanking DNA sequences.Abbreviations
LTR
long terminal repeat
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PBS
primer binding site
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PolII
RNA polymerase II
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bp
base pairs
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kb
kilobases (pairs)
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LINE
long interspersed sequence
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MHC
major histocompatibility complex
This paper is dedicated to the 90th birthday of Prof. Dr. Bernhard Rensch. |
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