| 自组装ELP多肽的从头设计及其在生物医药领域中的应用进展 |
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| 引用本文： | 杨国新,侯佳男,胡学军,杨君.自组装ELP多肽的从头设计及其在生物医药领域中的应用进展[J].生命的化学,2021(2):296-305. |
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| 作者姓名： | 杨国新 侯佳男 胡学军 杨君 |
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| 作者单位： | 大连理工大学生物工程学院;大连大学医学院 |
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| 基金项目： | 国家重点研发项目(2016YFD0200502);国家自然科学基金项目(31772193);中央高校基本科研业务费项目(DUT19TD38)。 |
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| 摘 要： | 重组类弹性蛋白多肽(elastin-like polypeptides, ELPs)是一种通过基因工程方法合成的多肽聚合物,其结构由类弹性蛋白的肽段单元重复串连组成,具有刺激响应性、自组装特性、显著的弹性和良好的生物学特性,如低血小板黏附性和低免疫原性等,因此ELPs材料已被广泛应用于组织工程、药物输送和纳米生物器件制备等生物医药应用领域。本文综合了国内外文献报道,简要介绍了ELPs的性质,重点阐述了ELPs自组装的设计原理、结构及其在药物控释等生物医药领域中的研究与应用进展。
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| 关 键 词： | ELPs 从头设计 自组装行为 药物控释 |
De novo design of self-assembled ELP peptides and their applications in biomedicine |
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| YANG Guoxin,HOU Jianan,HU Xuejun,YANG Jun.De novo design of self-assembled ELP peptides and their applications in biomedicine[J].Chemistry of Life,2021(2):296-305. |
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| Authors: | YANG Guoxin HOU Jianan HU Xuejun YANG Jun |
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| Institution: | (School of Bioengineering,Dalian University of Technology,Dalian 116024,China;Medical College,Dalian University,Dalian 116622,China) |
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| Abstract: | Recombinant elastin-like polypeptides(ELPs) are peptide polymers synthesized by genetic engineering. Their structure is composed of repeated series of elastin-like peptide units. With good biological properties, such as low platelet adhesion and low immunogenicity, ELPs materials have been widely used in tissue engineering, drug delivery and assembly of nano-biodevices. This review summarized the latest reports focusing on ELPs, briefly introduced the properties of ELPs, elaborated the design principles, and application progress in biomedicine. |
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| Keywords: | ELPs de novo design self-assembled behavior drug controlled release |
| 本文献已被 CNKI 维普 等数据库收录！ |
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