| 氧死亡:一种新型调节性细胞死亡 |
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| 引用本文： | 肖庆澳,夏旋. 氧死亡:一种新型调节性细胞死亡[J]. 生命的化学, 2021, 41(2): 223-230 |
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| 作者姓名： | 肖庆澳 夏旋 |
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| 作者单位： | 三峡大学医学院生理与病理生理学系,宜昌443002 |
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| 基金项目： | 湖北省卫生计生青年人才项目(WJ2015Q036)。 |
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| 摘 要： | 氧死亡(oxeiptosis)是2018年提出的一种新的调节性细胞死亡方式(regulated cell death,RCD).其特点是活性氧诱导的Caspase非依赖性的凋亡样细胞死亡.它有自身独特的损伤诱因(活性氧)、关健基因与通路(KEAP1-PGAM5-AIFM1),不同于坏死、细胞凋亡、坏死性凋亡、焦亡、铁死...
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| 关 键 词： | 氧死亡 调节性细胞死亡 凋亡 坏死 铁死亡 |
Oxeiptosis: a novel type of regulated cell death |
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| XIAO Qing'ao,XIA Xuan. Oxeiptosis: a novel type of regulated cell death[J]. Chemistry of Life, 2021, 41(2): 223-230 |
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| Authors: | XIAO Qing'ao XIA Xuan |
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| Affiliation: | (Department of Physiology and Pathophysiology,College of Medical Sciences,China Three Gorges University,Yichang 443002,China) |
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| Abstract: | Oxeiptosis was a newly-defined regulated cell death(RCD) in recent years. The characterization of oxeiptosis was reactive oxygen species(ROS)-induced Caspase-independent apoptosis-like cell death. Oxeiptosis was featured with unique inducer(ROS), key genes and cellular signaling pathway(KEAP1-PGAM5-AIFM1). There were significant differences with necrosis, apoptosis, necroptosis, pyroptosis, and ferroptosis. This review summarized the history, characteristics, key signaling pathway and differentiation with types of cell death. |
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| Keywords: | oxeiptosis regulated cell death apoptosis necrosis ferroptosis |
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