骨源活性物质的中枢调控功能

骨是机体的主要支持结构,也是参与机体运动和钙磷代谢的主要器官。骨也是一种潜在的新型内分泌器官,其通过骨细胞和骨髓分泌的多种生物活性物质,参与心血管、消化、内分泌等多个系统的生理和病理生理过程。骨源活性物质还可直接作用于中枢神经系统,参与脑功能和个体行为的调节,骨-脑轴的双向调控也逐渐引起了神经科学研究领域的关注。本文综述了骨源活性物质和骨源细胞对个体脑功能和脑疾病的调节作用以及相关神经精神疾病的发生发展,简介了其中枢调控功能的相关机制,为基于骨-脑调控轴的神经精神疾病机制研究和防治策略的建立拓宽了思路。

The roles of bone-derived active substances in central nervous system

Bone is not only the main supporting structure of the body, but also the main organ involved in body movement, calcium and phosphorus metabolism. Studies have shown that bone is also a potential new endocrine organ, which participates in the physiological and pathophysiological processes of cardiovascular, digestive and endocrine systems through a variety of bioactive substances secreted by bone cells and bone marrow. Bone derived active substances can also directly act on the central nervous system and participate in the regulation of brain function and individual behavior. The bidirectional regulation of bone brain axis has gradually attracted attention in the field of neuroscience. This review discussed the regulatory effects of bone derived active substances and bone derived cells on individual brain function and brain diseases, as well as the occurrence and development of related psychiatric diseases. The mechanism of central regulatory function is briefly introduced, which will broaden the thinking for the mechanism research and the establishment of prevention and treatment strategies of psychiatric diseases based on bone brain regulatory axis.