| 环氧二十碳三烯酸与肺部疾病的研究进展 |
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| 引用本文： | 梁贝贝,何桂媛,曾凡军.环氧二十碳三烯酸与肺部疾病的研究进展[J].生命的化学,2021(2):332-338. |
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| 作者姓名： | 梁贝贝 何桂媛 曾凡军 |
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| 作者单位： | 三峡大学第一临床医学院宜昌市中心人民医院呼吸内科 |
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| 基金项目： | 湖北省卫生计生西医类一般项目(WJ2015MB260);宜昌市医疗卫生科研项目(A20-2-003)。 |
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| 摘 要： | 环氧二十碳三烯酸(epoxyeicosatrienoic acids, EETs)是一种具有强大生物活性的内生脂质环氧化合物。EETs在肺组织疾病中具有抗炎症反应、抗氧化活性、诱导肺血管收缩、促进细胞增殖等作用,可成为多种肺部疾病防治的新型靶点。本文就EETs的作用机制及其在肺部疾病中的研究进展进行了归纳总结。
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| 关 键 词： | 环氧二十碳三烯酸 肺部疾病 细胞色素P450 |
Research progress on epoxyeicosapentaenoic acid and lung diseases |
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| LIANG Beibei,HE Guiyuan,ZENG Fanjun.Research progress on epoxyeicosapentaenoic acid and lung diseases[J].Chemistry of Life,2021(2):332-338. |
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| Authors: | LIANG Beibei HE Guiyuan ZENG Fanjun |
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| Institution: | (The First College of Clinical Medical Science,China Three Gorges University,Department of Respiratory Medicine,Yichang Central People's Hospital,Yichang 443003,China) |
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| Abstract: | Epoxyeicosatrienoic acids(EETs) are endogenous lipid epoxy compounds with powerful biological activity. EETs have anti-inflammatory response, antioxidant activity, induce pulmonary vasoconstriction, and promote cell proliferation in lung tissue diseases, and can become a new target for the prevention and treatment of various lung diseases. This review summarizes the mechanism of EETs and their research progress in lung diseases. |
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| Keywords: | epoxyeicosapentaenoic acid lung disease cytochrome P450 |
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