| 非酒精性脂肪肝病形成机制:补体和线粒体在其形成中的作用 |
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| 引用本文： | 邢娅,赵敏孟,刘龙,龚道清,耿拓宇.非酒精性脂肪肝病形成机制:补体和线粒体在其形成中的作用[J].生命的化学,2021,41(2):246-252. |
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| 作者姓名： | 邢娅 赵敏孟 刘龙 龚道清 耿拓宇 |
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| 作者单位： | 扬州大学表观遗传学及表观基因组学研究所,扬州225009 |
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| 基金项目： | 国家自然科学基金青年基金项目(31501945);国家自然科学基金面上项目(31472086);江苏高校优势学科建设工程资助项目(PAPD)。 |
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| 摘 要： | 非酒精性脂肪肝病(nonalcoholic fatty liver disease,NAFLD)作为一种流行性代谢疾病,一直是研究热点之一.NAFLD的形成涉及线粒体功能障碍、胰岛素抵抗、氧化应激、炎症反应等机制,而线粒体与补体在其中占据重要位置.然而,线粒体与补体在NAFLD形成过程中的内在关联及协同作用目前尚不十分...
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| 关 键 词： | 非酒精性脂肪肝病 线粒体 补体 氧化应激 炎症 |
The mechanism of nonalcoholic fatty liver disease: the roles of the complement and mitochondria in its development |
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| XING Ya,ZHAO Minmeng,LIU Long,GONG Daoqing,GENG Tuoyu.The mechanism of nonalcoholic fatty liver disease: the roles of the complement and mitochondria in its development[J].Chemistry of Life,2021,41(2):246-252. |
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| Authors: | XING Ya ZHAO Minmeng LIU Long GONG Daoqing GENG Tuoyu |
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| Institution: | (Institute of Epigenetics and Epigenomics,Yangzhou University,Yangzhou 225009,China) |
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| Abstract: | Nonalcoholic fatty liver disease(NAFLD), as an epidemic metabolic disease, has been one of the research hot topics for a long time. Recent studies have shown that the development of NAFLD involves mitochondrial dysfunction, insulin resistance, oxidative stress, inflammatory response and other mechanisms. In these mechanisms, mitochondria and the complement both play important roles. However, the internal connections and synergistic effects between mitochondria and the complement in the development of NAFLD are still poorly understood. This review focuses on the roles of mitochondria and complement in the development of NAFLD, and also proposes the hypothesis that the complement may participate in the development of NAFLD by acting on mitochondria, which will help address the mechanism underlying the development of NAFLD. |
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| Keywords: | nonalcoholic fatty liver disease mitochondria complement oxidative stress inflammation |
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