N-糖基化在肿瘤细胞逃逸CD8+T细胞中的意义和机制

肿瘤在发生发展过程中会产生异常糖基化结构,改变细胞功能,使其能逃逸机体细胞的免疫识别和免疫攻击,实现免疫逃逸。细胞膜表面蛋白的N-糖基化参与调控肿瘤细胞的增殖、迁移、侵袭、干细胞特性等。近年来,一系列研究进一步证实,肿瘤细胞免疫检查点分子的N-糖基化,以及识别N-糖基化的动物凝集素在肿瘤免疫逃逸CD8⁺T细胞中发挥了重要作用,如PD-L1的N-糖基化能增强其自身蛋白质的稳定性,促进与其受体PD-1的相互作用,并且靶向PD-1、PD-L1蛋白N-糖基化的抗体,能够有效抑制肿瘤免疫逃逸和肿瘤发展。

The significance and mechanism of N-glycosylation in tumor cells escaping from CD8+T cells

In the process of tumor occurrence and development,abnormal glycosylation structure will be produced,which will change cell function so that it can escape the immune recognition and immune attack of body cells,and achieve immune escape.The N-glycosylation of cell membrane surface proteins is involved in the regulation of tumor cell proliferation,migration,invasion,and stem cell characteristics.In recent years,a series of studies have further confirmed that N-glycosylation of tumor cell immune checkpoint molecules and animal lectins that recognize N-glycosylation play an important role in tumor immune escape CD8⁺T cells,such as PD-L1 N-glycosylation can enhance the stability of its own protein and promote the interaction with its receptor PD-1,meanwhile,antibodies targeting PD-1 and PD-L1 protein N-glycosylation can effectively inhibit tumor immune escape and suppression tumor development.