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Triaryl bis-sulfones as cannabinoid-2 receptor ligands: SAR studies |
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| Authors: | Shankar Bandarpalle B Lavey Brian J Zhou Guowei Spitler James A Tong Ling Rizvi Razia Yang De-Yi Wolin Ronald Kozlowski Joseph A Shih Neng-Yang Wu Jie Hipkin R William Gonsiorek Waldemar Lunn Charles A |
| Affiliation: | Department of Chemistry, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033-0539, USA. bandarpalle.shankar@spcorp.com |
| Abstract: | We recently reported that compound 1 is a potent inhibitor of the CB2 receptor with high selectivity over CB1. This paper describes the SAR development for this class of compounds. Variation of the substitution pattern on the aromatic rings, as well as the groups linking them together, led to sub-nanomolar inhibitors of the CB2 receptor, with high selectivity over CB1. |
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| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |