The crosstalk between autophagic and endo-/exosomal pathways in antigen processing for MHC presentation in anticancer T cell immune responses |
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Authors: | Liangshun You Liping Mao Juying Wei Shenhe Jin Chunmei Yang Hui Liu Li Zhu Wenbin Qian |
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Affiliation: | 1.Department of Hematology, The First Affiliated Hospital, College of Medicine,Zhejiang University,Hangzhou,China;2.Institute of Hematology, The First Affiliated Hospital, College of Medicine,Zhejiang University,Hangzhou,People’s Republic of China;3.Malignant Lymphoma Diagnosis and Therapy Center, The First Affiliated Hospital, College of Medicine,Zhejiang University,Hangzhou,China |
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Abstract: | T cells recognize antigen fragments from proteolytic products that are presented to them in the form of peptides on major histocompatibility complex (MHC) molecules, which is crucial for the T cell to identify infected or transformed cells. Autophagy, a process that delivers cytoplasmic constituents for lysosomal degradation, has been observed to provide a substantial source of intra- and extracellular antigens for MHC presentation to T cells, which will impact the tumor-specific immune response. Meanwhile, extracellular components are transported to cytoplasm for the degradation/secretion process by the endo-/exosomal pathway and are thus involved in multiple physiological and pathological processes, including immune responses. Autophagy and endo-/exosomal pathways are intertwined in a highly intricate manner and both are closely involved in antigen processing for MHC presentation; thus, we propose that they may coordinate in antigen processing and presentation in anticancer T cell immune responses. In this article, we discuss the molecular and functional crosstalk between autophagy and endo-/exosomal pathways and their contributions to antigen processing for MHC presentation in anticancer T cell immune responses. |
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