Adipose‐derived mesenchymal stem cells and regenerative medicine |
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| Authors: | Masamitsu Konno Atsushi Hamabe Shinichiro Hasegawa Hisataka Ogawa Takahito Fukusumi Shimpei Nishikawa Katsuya Ohta Yoshihiro Kano Miyuki Ozaki Yuko Noguchi Daisuke Sakai Toshihiro Kudoh Koichi Kawamoto Hidetoshi Eguchi Taroh Satoh Masahiro Tanemura Hiroaki Nagano Yuichiro Doki Masaki Mori Hideshi Ishii |
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| Affiliation: | 1. Department of Frontier Science for Cancer and Chemotherapy, Osaka University, , Suita, Osaka, 565‐0871 Japan;2. Department of Gastroenterological Surgery, Osaka University, , Suita, Osaka, 565‐0871 Japan;3. Department of Otorhinolaryngology‐Head and Neck Surgery, Osaka University, , Suita, Osaka, 565‐0871 Japan;4. Department of Surgery and Institute for Clinical Research, National Hospital Organization Kure Medical Center, , Hiroshima, 737‐0023 Japan |
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| Abstract: | Adipose tissue‐derived mesenchymal stem cells (ADSCs) are multipotent and can differentiate into various cell types, including osteocytes, adipocytes, neural cells, vascular endothelial cells, cardiomyocytes, pancreatic β‐cells, and hepatocytes. Compared with the extraction of other stem cells such as bone marrow‐derived mesenchymal stem cells (BMSCs), that of ADSCs requires minimally invasive techniques. In the field of regenerative medicine, the use of autologous cells is preferable to embryonic stem cells or induced pluripotent stem cells. Therefore, ADSCs are a useful resource for drug screening and regenerative medicine. Here we present the methods and mechanisms underlying the induction of multilineage cells from ADSCs. |
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| Keywords: | Adipose tissue‐derived mesenchymal stem cells multipotency regenerative medicine |
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