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Caspase‐7 participates in differentiation of cells forming dental hard tissues |
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| Authors: | Eva Matalova Herve Lesot Eva Svandova Tom Vanden Berghe Paul T Sharpe Christopher Healy Peter Vandenabeele Abigail S Tucker |
| Institution: | 1. Department of Physiology, University of Veterinary and Pharmaceutical Sciences, , Brno, Czech Republic;2. Institute of Animal Physiology and Genetics CAS, v.v.i., , Brno, Czech Republic;3. INSERM UMR 1109, Team “Osteoarticular and Dental Regenerative NanoMedicine”, , Strasbourg, France;4. Faculté de Chirurgie dentaire, Université de Strasbourg, , Strasbourg, France;5. Department for Molecular Biomedical Research, VIB, , Ghent, Belgium;6. Department of Molecular Biology, Ghent University, , Ghent, Belgium;7. Department of Craniofacial Development and Stem Cell Biology, King′s College London, , London, UK |
| Abstract: | Apoptosis during tooth development appears dependent on the apoptotic executioner caspase‐3, but not caspase‐7. Instead, activated caspase‐7 has been found in differentiated odontoblasts and ameloblasts, where it does not correlate with apoptosis. To further investigate these findings, the mouse incisor was used as a model. Analysis of caspase‐7‐deficient mice revealed a significant thinner layer of hard tissue in the adult incisor. Micro computed tomography scan confirmed this decrease in mineralized tissues. These data strongly suggest that caspase‐7 might be directly involved in functional cell differentiation and regulation of the mineralization of dental matrices. |
| Keywords: | ameloblast apoptosis caspase cell differentiation odontoblast |