Equine developmental orthopaedic diseases – a genome‐wide association study of first phalanx plantar osteochondral fragments in Standardbred trotters |
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| Authors: | S Lykkjen N I Dolvik M E McCue A K Rendahl J R Mickelson K H Røed |
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| Institution: | 1. Department of Basic Sciences and Aquatic Medicine, The Norwegian School of Veterinary Science, , N‐0033 Oslo, Norway;2. Department of Companion Animal Clinical Sciences, Section for Equine Medicine and Surgery, The Norwegian School of Veterinary Science, , Post‐box 8146 Dep, N‐0033, Oslo, Norway;3. Department of Veterinary Population Medicine, University of Minnesota, , St Paul, MN, 55108 USA;4. School of Statistics, University of Minnesota, , Minneapolis, MN, 55455 USA;5. Department of Veterinary and Biomedical Sciences, University of Minnesota, , St Paul, MN, 55108 USA |
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| Abstract: | Palmar/plantar osteochondral fragments (POF) in fetlock joints commonly affect and influence the athletic performance of horses. In this study, we used the Equine SNP50 BeadChip® to perform a genome‐wide association study of metatarsophalangeal POF in 176 Norwegian Standardbred trotter yearlings. Putative quantitative trait loci (QTL) for medial and/or lateral POF, and medial POF only were identified on ECA1, 2, 7, 9 and 31, whereas for lateral POF, only on ECA7, 11, 27 and X. The moderate number of QTL evidences a complex inheritance and suggests various genes controlling POF development in medial and lateral locations. |
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| Keywords: | Equine SNP50 BeadChip® horse osteochondrosis palmar/plantar osteochondral fragments quantitative trait loci |
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