Proteomic analysis of Taenia solium metacestode excretion-secretion proteins |
| |
Authors: | Victor Bjorn Kanobana Kirezi Gabriël Sarah Polman Katja Deckers Nynke Dorny Pierre Deelder André M Palmblad Magnus |
| |
Institution: | Veterinary Helminthology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium. bvictor@itg.be |
| |
Abstract: | The metacestode larval stage of Taenia solium is the causal agent of a zoonotic disease called cysticercosis. The disease has an important impact on pork trade (due to porcine cysticercosis) and public health (due to human neurocysticercosis). In order to improve the current diagnostic tools and to get a better understanding of the interaction between T. solium metacestodes and their host, there is a need for more information about the proteins that are released by the parasite. In this study, we used protein sequences from different helminths, 1DE, reversed-phase LC, and MS/MS to analyze the excretion-secretion proteins produced by T. solium metacestodes from infected pigs. This is the first report of the T. solium metacestode excretion-secretion proteome. We report 76 proteins including 27 already described T. solium proteins, 17 host proteins and 32 proteins likely to be of T. solium origin, but identified using sequences from other helminths. |
| |
Keywords: | Animal proteomics Excretion–secretion Mass spectrometry Taenia solium |
本文献已被 PubMed 等数据库收录! |
|