| 猪瘟病毒的重组分析 |
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| 引用本文： | 曹晟,张楚瑜,伊光辉. 猪瘟病毒的重组分析[J]. 遗传学报, 2005, 32(1): 52-56 |
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| 作者姓名： | 曹晟 张楚瑜 伊光辉 |
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| 作者单位： | 武汉大学生命科学学院动物病毒研究室,武汉,430072 |
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| 基金项目： | 国家重点基础研究发展规划“973”项目 (编号 :G19990 1190 5 )资助 ~~ |
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| 摘 要： | 以21株猪瘟病毒的编码序列作为研究对象，通过对基因树的比较和四重体分析，研究猪瘟病毒毒株间可能的重组关系。分析结果表明，ALD(D49532)与GPE-(D49533)问可能有一重组片段E0、E1和E2，而持续感染毒株CSFV39(AF407339)中的NS5A-NS5B可能来源于Shimen强毒株(AF092448)，这说明不同猪瘟病毒极有可能在自然环境或减毒疫苗的应用过程中由于混合感染而发生遗传物质的交换，从而适应宿主环境的改变，并产生特殊的表型。
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| 关 键 词： | 猪瘟病毒 重组 基因树 四重体 |
| 文章编号： | 0379-4172(2005)01-0052-05 |
Recombinant Analysis of Classical Swine Fever Virus |
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| CAO Sheng,ZHANG Chu-yu,YI Guang-Hui. Recombinant Analysis of Classical Swine Fever Virus[J]. Journal of Genetics and Genomics, 2005, 32(1): 52-56 |
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| Authors: | CAO Sheng ZHANG Chu-yu YI Guang-Hui |
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| Abstract: | To study the possible recombinant relationship among differently derived classical swine fever virus,the coding regions of 21 isolates were analyzed to detect recombination and breakpoints through gene trees comparison and quartet analyses.The results show nucleotide area corresponding to E0,E1 and E2 as a possible recombinant tract between ALD (D49532) and GPE-(D49533) while NS5A-NS5B of the isolate 39 (AF407339) appears to be derived from a virulent Shimen strain (AF092448) sequence.This suggests that intertypic exchanges of genetic materials during mixed infections under natural or laboratorial conditions can lead classical swine fever virus to adapt to the changes of host environment. |
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| Keywords: | classical swine fever virus recombination gene tree quartet |
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