| 被动吸烟对雌性卵巢功能的影响 |
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| 引用本文： | 周福波,李若葆,吴慧丽,薛德娜. 被动吸烟对雌性卵巢功能的影响[J]. 现代生物医学进展, 2010, 10(5) |
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| 作者姓名： | 周福波 李若葆 吴慧丽 薛德娜 |
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| 作者单位： | 1. 潍坊医学院,山东,潍坊,261042
2. 潍坊医学院解剖学研究室,山东,潍坊,261042 |
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| 基金项目： | 山东省医药卫生科技发展计划项目(2007HZ021) |
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| 摘 要： | 目的:探讨被动吸烟对雌性Wistar大鼠卵巢结构和功能的影响。方法:雌性Wistar鼠32只,随机分为对照组和被动吸烟组,对照组在自然环境下饲养,吸烟组在自制的吸烟箱内被动吸烟3个月,吸烟三个月后,对两组分别进行秤重,然后处死。用测量仪器测量母鼠卵巢的大小、重量,并做光、电镜观察,免疫组织化学检测ER、PR、FSHR、LHR在卵巢中的表达,所得数据进行统计学处理。结果:吸烟三个月大鼠卵巢充血性囊性退变,皮质萎缩,卵泡颗粒细胞排列紊乱;生长卵泡的颗粒细胞松散变性,排列不整齐;卵泡数减少,成熟的卵母细胞数目明显减少;髓质血管收缩,减少;间质疏松。②电镜对照组可见多个卵泡细胞,细胞内有空白颗粒及高密度颗粒。吸烟组可见多个颗粒细胞层,内有增粗的内质网、核糖体;核周隙局部增宽,线粒体模糊;线粒体水样变、空泡样变,线粒体嵴断裂、模糊;内质网脱颗粒样变。与没有吸烟的正常大鼠B组比较,吸烟大鼠的ER、PR、FSHR、LHR减少(P<0.05)。结论:被动吸烟组雌性卵巢充血性囊性退变,皮质萎缩,卵泡颗粒细胞排列紊乱。
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| 关 键 词： | 被动吸烟 卵巢 Wistar大鼠 |
The influence of passive smoking on the ovary's function |
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| ZHOU Fu-bo,LI Ruo-bao,WU Hui-li,XUE De-na. The influence of passive smoking on the ovary's function[J]. Progress in Modern Biomedicine, 2010, 10(5) |
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| Authors: | ZHOU Fu-bo LI Ruo-bao WU Hui-li XUE De-na |
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| Affiliation: | ZHOU Fu-bo LI Ruo-bao WU Hui-li XUE De-na (1 Graduate Student at Wei Fang Medical University,2 Weifang Medical University Anatomy Laboratory,Sh,ong Weifang china 261042) |
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| Abstract: | Objective:Effects of passive smoking on ovarian function in female wistarrats and its impact on embryonic development.Methods:32 female Wistar rats were randomly divided into control group and the passive smoking group and the control group reared in the natural environment,smoking in the home-made smoking group box 3 months of passive smoking,smoking after three months of weighing the two groups separately,and then executed.Rats by measuring instruments measuring ovarian size,weight,and so light,electron m... |
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| Keywords: | passive smoking ovary Wistar rats |
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