Effect of the lantibiotic warnerin on lipid bilayer membranes |
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| Authors: | M. P. Borisova V. P. Korobov L. M. Lemkina N. V. Pan’kova G. N. Likhatskaya |
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| Affiliation: | 1.Institute of Theoretical and Experimental Biophysics,Russian Academy of Sciences,Pushchino, Moscow Region,Russia;2.Institute of Ecology and Genetics of Microorganisms,Russian Academy of Sciences, Urals Division,Perm,Russia;3.Pacific Institute of Bioorganic Chemistry,Russian Academy of Sciences, Far-Eastern Division,Vladivostok,Russia |
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| Abstract: | The effect of the lantibiotic warnerin on the ionic permeability of artificial membranes was studied. Membranes were composed of different lipid fractions, including lipids isolated from warnerin-sensitive cells of Staphylococcus epidermidis. Warnerin was shown to selectively interact with artificial membranes of different lipid composition, which in some cases led to formation of ion channels. Computer modeling of warnerin spatial structure supported the probable membranotropic activity of the peptide. |
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