Repair of deaminated cytosine residues of DNA: biological significance of the absence of uracil from DNA. |
| |
Authors: | H Hayakawa M Sekiguchi |
| |
Institution: | Department of Biology, Faculty of Science, Kyushu University 33, Fukuoka 812, Japan |
| |
Abstract: | Uracil-DNA glycosylase of is involved in repair of deaminated cytosine residues of DNA. Survivals of SPO2 phage after treatment with bisulfite and weak alkali are considerably higher in wild type strains than in mutants, which are deficient in the enzyme activity, whereas survivals of bisulfite/alkali-treated PBS1 phage in the two types of cells are essentially the same. The spontaneous mutation frequency of a mutant is three fold higher than is that of a wild type strain. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|