Electrospray ionization mass spectrometry of platinum anticancer agents. |
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Authors: | G K Poon P Mistry S Lewis |
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Affiliation: | Drug Development Section, Institute of Cancer Research, Sutton, Surrey, UK. |
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Abstract: | Quantification and identification of platinum drugs and their metabolites in biological samples has always been difficult because these compounds are thermally unstable, non-volatile and insoluble. We have demonstrated that electrospray ionization mass spectrometry can be a valuable technique for direct mass spectral analysis of platinum anticancer agents and for obtaining structural information as a result of fragmentation. Full-scan spectra were obtained with approximately 10 pmol samples. These results show the potential of applying this technique in pharmacokinetic studies of platinum anticancer drugs. |
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