缺锌对大鼠血液皮质醇和ACTH含量及大脑皮质NO合酶活性的影响 |
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引用本文: | 刘燕强,顾景范. 缺锌对大鼠血液皮质醇和ACTH含量及大脑皮质NO合酶活性的影响[J]. 动物学研究, 2001, 22(5): 429-432 |
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作者姓名: | 刘燕强 顾景范 |
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作者单位: | 1. 南开大学生命科学学院 2. 军事医学科学院卫生学环境医学研究所 |
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基金项目: | 国家自然科学基金,教育部科学技术研究项目,39700120,A94107,, |
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摘 要: | 就缺锌对大鼠血液皮质醇和促肾上腺皮质激素(ACTH)含量以及大脑皮质NO合酶活性的影响进行了研究,生长大鼠随机分为3组,即缺锌组,对喂组和缺锌补锌组(先饲喂缺锌饲料21天后再补锌),饲养实验的持续时间为35d。与对喂组比较,缺锌组大鼠血液中皮质醇含量显著升高,而血液ACTH浓度以及大脑皮质NO合酶活性明显降低,此结果提示锌可影响下丘脑-垂体一肾上腺皮质轴和NO合酶的代谢。
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关 键 词: | 缺锌 皮质醇 ACTH NO合酶 血液 大脑皮质 大鼠 酶活性 学习 记忆 |
文章编号: | 0254-5853(2001)05-0429-04 |
Effect of Zinc Deficiency on Blood Cortisol and ACTH Concentrations,Cerebrum Cortex NO Synthase Activity in Rat |
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Abstract: | The effects of zinc deficiency on the serum cortisol and adrenocorticotrophic hormone (ACTH) concentration,and the cerebrum nitric oxide synthase (NOS) activity in rats were studied.Growing rats were allotted to three groups,which were zinc deficiency (ZD),paired fed (PF) and zinc supplementation after feeding zinc deficient food for 21 days (ZS).The duration of feed test was 35 days.Compared with PF rats,serum cortisol concentration in ZD ones was significantly increased,whereas serum ACTH concentration and cerebrum NOS activity were significantly decreased.The results suggested that zinc might influence the metabolism of hypothalamic hypophysial adrenocortical axis and NOS. |
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Keywords: | Zinc deficiency Cortisol ACTH NO synthase |
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