Emerging roles of PDGF-D signaling pathway in tumor development and progression |
| |
Authors: | Zhiwei Wang Aamir Ahmad Yiwei LiDejuan Kong Asfar S AzmiSanjeev Banerjee Fazlul H Sarkar |
| |
Institution: | Department of Pathology, Karmanos Cancer Institute, Wayne State University, School of Medicine, Detroit, MI 48201, USA |
| |
Abstract: | Platelet-derived growth factor-D (PDGF-D) can regulate many cellular processes, including cell proliferation, apoptosis, transformation, migration, invasion, angiogenesis and metastasis. Therefore PDGF-D signaling has been considered to be important in human malignancies, and thus PDGF-D signaling may represent a novel therapeutic target, and as such suggests that the development of agents that will target PDGF-D signaling is likely to have a significant therapeutic impact on human cancers. This mini-review describes the mechanisms of signal transduction associated with PDGF-D signaling to support the role of PDGF-D in the carcinogenesis. Moreover, we summarize data on several PDGF-D inhibitors especially naturally occurring “chemopreventive agent” such an indole compound, which we believe could serve as a novel agent for the prevention of tumor progression and/or treatment of human malignancies by targeted inactivation of PDGF-D signaling. |
| |
Keywords: | PDGF-D Cancer Signaling Therapy Nutrition |
本文献已被 ScienceDirect 等数据库收录! |
|