The human urinary proteome contains more than 1500 proteins, including a large proportion of membrane proteins |
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| Authors: | Jun Adachi Chanchal Kumar Yanling Zhang Jesper V Olsen Matthias Mann |
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| Institution: | (1) Department of Proteomics and Signal Transduction, Max-Planck Institute for Biochemistry, Am Klopferspitz, D-82152, Martinsried, Germany;(2) Center for Experimental Bioinformatics, University of Southern Denmark, Campusvej, DK-5230, Odense M, Denmark;(3) Graduate School of Global Environmental Studies, Kyoto University, Yoshida-Honmachi Sakyo-Ku, Kyoto, Japan;(4) Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 101300, China |
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| Abstract: | Background Urine is a desirable material for the diagnosis and classification of diseases because of the convenience of its collection
in large amounts; however, all of the urinary proteome catalogs currently being generated have limitations in their depth
and confidence of identification. Our laboratory has developed methods for the in-depth characterization of body fluids; these
involve a linear ion trap-Fourier transform (LTQ-FT) and a linear ion trap-orbitrap (LTQ-Orbitrap) mass spectrometer. Here
we applied these methods to the analysis of the human urinary proteome. |
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