ProtRepeatsDB: a database of amino acid repeats in genomes |
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Authors: | Mridul K Kalita Gowthaman Ramasamy Sekhar Duraisamy Virander S Chauhan and Dinesh Gupta |
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Institution: | (1) Structural and Computational Biology Group, Malaria Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi, 110067, India;(2) Dana-farber Cancer Institute, Harvard Medical School, Dana-830, 44-Binney street, Boston, MA 02115, USA;(3) Malaria Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi, 110067, India |
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Abstract: | Background Genome wide and cross species comparisons of amino acid repeats is an intriguing problem in biology mainly due to the highly
polymorphic nature and diverse functions of amino acid repeats. Innate protein repeats constitute vital functional and structural
regions in proteins. Repeats are of great consequence in evolution of proteins, as evident from analysis of repeats in different
organisms. In the post genomic era, availability of protein sequences encoded in different genomes provides a unique opportunity
to perform large scale comparative studies of amino acid repeats. ProtRepeatsDB is a relational database of perfect and mismatch repeats, access to which is designed as a resource and collection of tools
for detection and cross species comparisons of different types of amino acid repeats. |
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