Relative contribution of two mechanisms to post-stimulus hyperpolarization in leech retzius cells |
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| Institution: | 1. Volen Center for Complex Systems and Department of Biology, Brandeis University, 415 South Street, Waltham, MA 02454, USA;2. Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, 211 CRB, 415 Curie Boulevard, Philadelphia, PA 19104, USA;1. Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York;2. Department of Mathematics, National Autonomous University of Mexico, Mexico City, Mexico;3. Biology Department, Volen Center, Brandeis University, Waltham, Massachusetts;4. Department of Engineering, University of Cambridge, Cambridge, United Kingdom;1. Biology Department and Volen Center, Brandeis University, Waltham, MA 02454, USA |
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| Abstract: | - 1.1. In Retzius cells of the horse leech, Haemopis sanguisuga, intensive firing is followed by prolonged post-stimulus hyperpolarization (PSH) mediated by an increase in K-conductance and activation of the electrogenic sodium pump.
- 2.2. The recovery of membrane potential during PSH can be described by a biexponential model from which the relative contribution of the early and the late component to the peak amplitude of PSH may be calculated.
- 3.3. The time course of the calculated early component coincides with the time course of changes that occur in input membrane resistance during PSH.
- 4.4. The relative contribution of the late component increases linearly with an increase in stimulus duration. The rate constants of the two phases did not change with changes in stimulus duration.
- 5.5. It was concluded that the proposed model is useful for the estimation of the relative contribution and kinetics of two PSH mediating mechanisms (K-conductance increase and activation of an electrogenic sodium pump) in different experimental conditions.
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