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Enhanced phosphatidylinositol kinase activity is associated with early stages of hepatocarcinogenesis and hepatocellular carcinoma |
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| Authors: | J W Olson |
| Affiliation: | 1. Division of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois;2. Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health, San Antonio, Texas;3. Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois;4. South Texas Veterans Health Care System, San Antonio, Texas;1. Center for Science, Health, and Society, Case Western Reserve University School of Medicine, Cleveland, Ohio;2. Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio;3. Departments of Internal Medicine, Pediatrics, and Population and Quantitative Health Sciences and the Center for Clinical Informatics Research and Education, The MetroHealth System, Cleveland, Ohio;4. Center for Artificial Intelligence in Drug Discovery, Case Western Reserve University School of Medicine, Cleveland, Ohio |
| Abstract: | Liver phosphatidylinositol (PI) kinase activity was determined in rats exposed to two different hepatocarcinogenic regimens. In contrast to partial treatment regimens the complete Solt and Farber hepatocarcinogenic regimen caused a significant increase in liver PI kinase activity at day 11 after partial hepatectomy. PI kinase activity in hepatocarcinomas removed 15 1/2 months after initiation of the complete Solt and Farber regimen was 2-fold higher than normal liver tissue surrounding the tumors. Compared to a choline supplemented diet a hepatocarcinogenic regimen consisting of a diet deficient in choline and methionine significantly increased liver PI kinase activity after 26 days. These data demonstrate that liver PI kinase activity is selectively elevated during hepatocarcinogenesis. |
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