Biodegradable and pH-sensitive hydrogels for cell encapsulation and controlled drug release |
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Authors: | Wu De-Qun Sun Yun-Xia Xu Xiao-Ding Cheng Si-Xue Zhang Xian-Zheng Zhuo Ren-Xi |
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Institution: | Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry,Wuhan University, Wuhan 430072, People's Republic of China. |
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Abstract: | Hydrogels with pH-sensitive poly(acrylic acid) (PAAc) chains and biodegradable acryloyl-poly(-caprolactone)-2-hydroxylethyl methacrylate (AC-PCL-HEMA) chains were designed and synthesized. The morphology of hydrogel was observed by scanning electron microscopy. The degradation of the hydrogel in the presence of Pseudomonas lipase was studied. The in vitro release of bovine serum albumin from the hydrogel was investigated. Cytotoxicity study shows that the AC-PCL-HEMA/AAc copolymer exhibits good biocompatibility. Cell adhesion and migration into the hydrogel networks were evaluated by using different cell lines. The hydrogel with a lower cross-linking density and a larger pore size exhibited a better performance for cells migration. |
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