Integration of Bayesian molecular clock methods and fossil-based soft bounds reveals early Cenozoic origin of African lacertid lizards |
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Authors: | Christy A Hipsley Lin Himmelmann Dirk Metzler and Johannes Müller |
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Institution: | (1) Museum f?r Naturkunde – Leibniz-Institut f?r Evolutions- und Biodiversit?tsforschung, Humboldt-Universit?t zu Berlin, Invalidenstr. 43, 10115 Berlin, Germany;(2) Department of Ecology and Evolutionary Biology, University of California, A316 Earth and Marine Sciences Building, 95064 Santa Cruz, CA, USA;(3) Institut f?r Informatik, Goethe-Universit?t, Robert Mayer Str. 11-15, D-60325 Frankfurt am Main, Germany;(4) Department of Biology, University of Munich (LMU), Grosshaderner Str. 2, D-82152 Planegg-Martinsried, Germany |
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Abstract: | Background Although current molecular clock methods offer greater flexibility in modelling evolutionary events, calibration of the clock
with dates from the fossil record is still problematic for many groups. Here we implement several new approaches in molecular
dating to estimate the evolutionary ages of Lacertidae, an Old World family of lizards with a poor fossil record and uncertain
phylogeny. Four different models of rate variation are tested in a new program for Bayesian phylogenetic analysis called TreeTime,
based on a combination of mitochondrial and nuclear gene sequences. We incorporate paleontological uncertainty into divergence
estimates by expressing multiple calibration dates as a range of probabilistic distributions. We also test the reliability
of our proposed calibrations by exploring effects of individual priors on posterior estimates. |
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