The synthesis and in vitro testing of structurally novel antibiotics derived from acylnitroso Diels-Alder adducts |
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Authors: | Nora George P Miller Marvin J Möllmann Ute |
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Institution: | Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA. |
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Abstract: | The structural similarity between beta-lactam antibiotics, such as penicillin, and isoxazolidine-3,5-dicarboxylic acids led to the hypothesis that isoxazolidine-3,5-dicarboxylic acids could be effective analogs of beta-lactam antibiotics. The syntheses of relevant isoxazolidine-3,5-dicarboxylic acids from acylnitroso Diels-Alder adducts and subsequent biological testing have shown that these first examples are inhibitors of Escherichia coli X580. |
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