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Small cytosolic double-stranded DNA represses cyclic GMP-AMP synthase activation and induces autophagy
Affiliation:1. Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing 400016, P.R. China;2. Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325015, P.R. China;3. Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China
Abstract:
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  • Keywords:cGAS  PI3KC3  STING  autophagy  DNA damage  interferon β  small cytosolic double-stranded DNA  CP: Immunology  CP: Molecular biology
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