Biological principles of adult degenerative scoliosis |
| |
| Affiliation: | 1. Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA;1. Department of Spine Surgery, Hong Hui Hospital, Xi''an Jiaotong University Health Science Center, No. 555 East Youyi Rd, Beilin District, Xi''an 710054, Shan''xi, China;2. Department of General Surgery, The 417th Hospital, China National Nuclear Corporation (CNNC), No. 5 Kangfu Rd, Lintong District, Xi''an 710061, Shan''xi, China;1. Key Laboratory of Neuroscience, School of Basic Medical Science, Guangzhou Medical University, Guangzhou 511436, China;2. Institute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou 510260, China;3. Department of Spine Surgery, First Affiliated Hospital of Sun Yet-Sen University, Guangzhou 510080, China;1. BGI-Shenzhen, Shenzhen, Guangdong 518103, China;2. First University Department of Respiratory Medicine, ‘Sotiria’ Hospital, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece;3. Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece;1. Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY 10029, USA;3. Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA |
| |
| Abstract: | The global aging population has led to an increase in geriatric diseases, including adult degenerative scoliosis (ADS). ADS is a spinal deformity affecting adults, particularly females. It is characterized by asymmetric intervertebral disc and facet joint degeneration, leading to spinal imbalance that can result in severe pain and neurological deficits, thus significantly reducing the quality of life. Despite improved management, molecular mechanisms driving ADS remain unclear. Current literature primarily comprises epidemiological and clinical studies. Here, we investigate the molecular mechanisms underlying ADS, with a focus on angiogenesis, inflammation, extracellular matrix remodeling, osteoporosis, sarcopenia, and biomechanical stress. We discuss current limitations and challenges in the field and highlight potential translational applications that may arise with a better understanding of these mechanisms. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
