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The malate-aspartate shuttle is important for de novo serine biosynthesis
Institution:1. Department of Genetics, Section Metabolic Diagnostics, University Medical Center Utrecht, Lundlaan 6, 3584 EA Utrecht, the Netherlands;2. Emma Center for Personalized Medicine, Departments of Pediatrics and Human Genetics, Amsterdam University Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands;3. Departments of Pediatrics and Laboratory Medicine, Laboratory Genetic Metabolic Diseases, Amsterdam University Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands;4. dLAB, Center for Molecular Medicine, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands
Abstract:
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  • Keywords:malate-aspartate shuttle  NADH shuttle  malate dehydrogenase  isotope-tracer analysis  serine biosynthesis  glycolysis  metabolomics  central carbon metabolism  CP: Metabolism
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