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NRF2 activation induces NADH-reductive stress,providing a metabolic vulnerability in lung cancer
Institution:1. Center for Cancer Research, Massachusetts General Hospital, Boston, MA 02114, USA;2. Department of Pathology, New York University Grossman School of Medicine, 550 First Avenue, New York, NY 10016, USA;3. Laura and Isaac Pelmutter Cancer Center, New York University Langone Health, New York, NY 10016, USA;4. Department of Cell Biology, Blavatnik Institute Harvard Medical School, Boston, MA 02115, USA;5. Cutaneous Biology Research Center, Massachusetts General Hospital, Boston, MA 02114, USA;6. The MGH Center for Regenerative Medicine, Harvard Medical School, Boston, MA 02114, USA;7. Department of Medicine, Harvard Medical School, Boston, MA 02114, USA;1. Department of Biochemical Sciences, Sapienza University of Rome, 00185 Rome, Italy;2. Department of Chemistry, Center of Membrane Sciences, and Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40506, United States;1. Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA;2. Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT 06510, USA;3. Department of Radiology & Biomedical Imaging, Yale School of Medicine, New Haven, CT 06510, USA;4. Departments of Psychiatry & Biomedical Engineering, Yale School of Medicine, New Haven, CT 06510, USA;1. Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA;2. Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA;3. University of Michigan Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA;4. Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA;5. Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI, USA;6. Department of Biochemistry, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt;7. Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA;8. Department of Pathology, University of Michigan, Ann Arbor, MI, USA;9. Department of Surgery, University of Michigan, Ann Arbor, MI, USA;10. Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA;12. TTK Cancer Biomarker Research Group, Institute of Enzymology, Budapest, Hungary;13. Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA;14. Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA;15. Veteran’s Affairs Ann Arbor Healthcare System, Ann Arbor, MI, USA;1. Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27701, USA;2. Department of Medicine, Division of Endocrinology, Metabolism, and Nutrition, Duke University Medical Center, Durham, NC 27710, USA;3. Department of Medicine, Division of Geriatrics, Duke University Medical Center, Durham, NC 27710, USA;4. Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA;1. Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390, USA;2. Laboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA;3. Live Cell Imaging Core Facility, UT Southwestern Medical Center, Dallas, TX 75390, USA;4. Division of Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA;5. Department of Biochemistry, UT Southwestern Medical Center, Dallas, TX 75390, USA;6. Howard Hughes Medical Institute, UT Southwestern Medical Center, Dallas, TX 75390, USA;7. Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX 75390, USA;1. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA;2. MRC Cancer Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XZ, UK;3. University College London, London WC1E 6BT, UK;4. Department of Oncology, CRUK Cambridge Institute, Cambridge Biomedical Campus, Cambridge CB2 0RE, UK;5. Division of Endocrinology, Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA;6. Department of Molecular Biology and Biochemistry, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA;7. Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore;8. Institute for Molecular & Cell Biology, Agency for Science, Technology and Research (A1STAR), Singapore 138648, Singapore;9. Northwell Health Cancer Institute, Northwell Health, New Hyde Park, NY 11042, USA;10. Ludwig Princeton Branch, Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ 08544, USA
Abstract:
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  • Keywords:NRF2-KEAP1 pathway  reductive stress  non-small cell lung cancer  functional genomic  oxidative phosphorylation
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