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Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans
Affiliation:1. The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel;2. Departments of Neuroscience and Genetics, Yale School of Medicine, New Haven, CT, USA;3. Department of Chemistry, Bar-Ilan University, Ramat Gan, Israel;4. Ilse Katz Institute for Nanoscale Science & Technology, Ben-Gurion University of the Negev, Beer-Sheva, Israel;5. Henry Wellcome Building for Biocatalysis, Biosciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK;6. European Molecular Biology Laboratory, Grenoble, France
Abstract:
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  • Keywords:SARM1  TIR-1  neurodegeneration  cryo-EM  structural biology  axon  Wallerian degeneration  CP: Molecular biology  CP: Neuroscience
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