Revised Case Finding Protocol for Dysglycemia in Chile: A Call for Action in Other Populations |
| |
| Institution: | 1. Precision Care Clinic Corp, Saint Cloud, Florida;2. Department of Global Health and Population, Harvard TH Chan School of Public Health, Harvard University, Boston, Massachusetts;3. Foundation for Clinic, Public Health, and Epidemiology Research of Venezuela (FISPEVEN INC), Caracas, Venezuela;4. Division of Endocrinology, Diabetes and Bone Disease, The Marie-Josée and Henry R. Kravis Center for Cardiovascular Health at Mount Sinai Heart, Icahn School of Medicine at Mount Sinai, New York, New York;5. International Clinical Research Center, St Anne’s University Hospital (ICRC-FNUSA), Brno, Czech Republic;6. Public Health Research Unit, Department of Social and Preventive Medicine, School of Medicine, Universidad Centro-Occidental “Lisandro Alvarado”, Barquisimeto, Venezuela;7. Department of Physiology and Biophysics, School of Medicine, Georgetown University, Washington, District of Columbia;8. Nutrition and Diabetes Unit, Clínica Red Salud Vitacura, Santiago, Chile;9. Nutrition and Diabetes Service, Santiago Military Hospital, Santiago, Chile;10. Universidad de Los Andes, Santiago, Chile;1. Department of Endocrinology and Nutrition, Ramón y Cajal University Hospital, Madrid, Spain;2. Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain;3. Department of Medicine, Universidad de Alcalá, Madrid, Spain;4. Department of Biochemistry, Ramón y Cajal University Hospital, Madrid, Spain;5. Department of Biochemistry and Molecular Genetics, Hospital Clinic, Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), Barcelona, Spain;6. Department of Endocrinology and Nutrition. Hospital Clinic, IDIBAPS, Barcelona, Spain;7. Department of Diagnostic Imaging, Ramón y Cajal University Hospital, Madrid, Spain;8. Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain;1. Department of Medicine, Laniado Hospital, Sanz Medical Center, Netanya, Israel;2. Faculty of Medicine, Hebrew University and Hadassah Medical School, Jerusalem, Israel;1. Endocrine Institute, Meir Medical Center, Kfar Saba, Israel;2. Orthopedic Department, Meir Medical Center, Kfar Saba, Israel;3. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel;1. Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland;2. Department of Epidemiology, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, Florida;3. Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Johns Hopkins University, Baltimore, Maryland;4. Section on Hospital Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina;5. Center for Prevention of Cardiovascular Disease, Section on Cardiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina;1. Institute of Endocrinology, Diabetes and Metabolism, Meir Medical Center, Kfar Saba, Israel;2. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel;3. Research Institute, Meir Medical Center, Kfar Saba, Israel |
| |
| Abstract: | ObjectiveGuidelines recommend case finding for dysglycemia (prediabetes and type 2 diabetes T2D]) in adults or youth older than 10 years with overweight/obesity, but increased adiposity has not been associated with dysglycemia in some Hispanic populations. This study aims to determine the prevalence of dysglycemia in this population using simplified criteria independent of body mass index and age to request an oral glucose tolerance test (OGTT).MethodsCross-sectional retrospective analysis of medical records from a clinical center in Chile (2000-2007). OGTT was obtained from any patient with 1 cardiometabolic risk factor (CMRF) independent of age and body mass index.ResultsIn total, 4969 adults (mean age ± SD) 45.7 ± 15.9 years and 509 youths 16.6 ± 3.0 years were included. The prevalence (%, 95% CI) of prediabetes doubled that of T2D in youths (14.1%, 1.4-17.4 vs 6.3%, 4.5-8.7) and tripled it in adults (36.0%, 34.7-37.4 vs 10.7%, 9.8-11.5). In underweight and normal-weight adults, 22% (12.0-36.7) and 29.2% (26.4-32.1) had prediabetes, whereas 4.9% (1.3-16.1) and 8.8% (7.2-10.7) had T2D, respectively. In normal weight youths, 10.5% (6.7-15.9) and 2.9% (1.2-6.6) had prediabetes and T2D, respectively. In adults, but not in youths, most dysglycemia categories were related to overweight/obesity.ConclusionThis study supports a public health policy to identify more people at risk for cardiovascular disease by implementing a revised case finding protocol for dysglycemia using OGTT in even normal weight patients over 6 years of age when there is at least 1 CMRF. Reanalysis of case finding protocols for cardiometabolic risk in other populations is warranted. |
| |
| Keywords: | type 2 diabetes prediabetes impaired glucose tolerance prevalence Chile case finding |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
